Purpose: The prescribed treatment dose, routinely calculated on the planning CT and approved by the radio-oncologist, is assumed as the dose applied for the whole treatment (ApprovedTD). However, in online daily adaptive proton therapy (DAPT), the plan is optimized on the daily CT to correct for anatomical daily changes, while the patient is lying on the treatment table. Intrinsically, both...
Purpose
When performing online adaptive radiation therapy (ART), dosimetric measurements of the treatment plan of the day with the aid of a phantom before applying the dose to the patient is not possible. Typically, a dose recalculation with an independent system is done in this situation. In order to verify the accuracy of the dose distributions delivered by these online ART plans, for a...
Glioblastoma (GBM) is the most frequent primary brain tumor with dismal prognosis after radiation therapy, a standard treatment option for this disease. Recently, RT has been investigated as a mediator of effects of T cell-based therapies in the context of immunosuppressive GBM microenvironment. The MET receptor is an oncogene involved in radiation resistance, and stem-like properties of GBM....
Purpose: Radiation therapy is a standard therapy option in many cancer types. Recently, improved effects were observed when radiation therapy was combined with immunotherapy such as immune checkpoint inhibitors. Indeed, radiation therapy has a systemic immunomodulatory effect by stimulating cancer immunity cycle through the release of cancer antigens and improving immune infiltration. Besides,...
Purpose
Before the extraction of radiomic features, images are usually interpolated to a common resolution. Furthermore, a number of different radiomic feature extraction software exist. Here, we investiage how choice of interpolation resolution and feature extraction software affects stability of radiomic features.
Methods
Following work quantifies this influence on the radiomic...
Purpose:
In radiomic studies, robustness of models can be challenging due to variations in feature values caused by different scanners and imaging protocols. This problem is most prominent in magnetic resonance imaging (MRI) due its high sensitivity to imaging parameters. This study aims to assess the impact of image preprocessing, and image-normalization on the stability of MRI-based...
Purpose: This study evaluated pretreatment FDG-PET/CT-based radiomic signatures for prediction of hyperprogression in metastatic melanoma patients treated with immune checkpoint inhibition (ICI).
Material and method: 56 consecutive metastatic melanoma patients treated with ICI and available imaging were included in our study and 330 metastatic lesions were individually segmented on...
Purpose: To experimentally assess the technical feasibility and quantify the mechanical accuracy of respiratory gating during dynamic trajectory radiotherapy (DTRT) plan delivery. DTRT extends VMAT by dynamic table and collimator rotation during beam-on.
Methods: An HexaMotion motion stage positioned on the treatment table of a TrueBeam system is used to reproduce four different...
Purpose
To estimate influence of adding tolerance levels (TL) to ultimate action levels (AL) in quality control (QC) of equipment geometrical precision in stereotactic radiotherapy on size of safety margins (SMs) and, consequentially, planning target volumes (PTVs) in frameless image-guided stereotactic intracranial radiosurgery and radiotherapy (SRS/SRT) delivered with the Accuray...
