Purpose: Temporally feathered radiotherapy (TFRT) replaces a standard treatment plan by 5 iso-curative sub-plans (López Alfonso et al. Med Phys 2018). Each sub-plan is created such that one of five chosen organs-at-risk (OARs) receives a higher dose compared to the standard plan in one fraction, allowing the other four OARs to receive a lower dose. Each OAR then receives one high and four low...
Purpose:
Accurate and realistic dose accumulation in external beam radiotherapy planning becomes increasingly important in the context of repeat irradiations to returning patients. Rather than straight sums of physical dose, radiotherapy professionals prefer biologically weighted dose estimates to support prescription of repeat irradiations. This work presents a framework for creating...
Purpose:
Particle therapy has shown clinical advantages over conventional radiation therapy, particularly for head and neck cancer and pediatric brain cancer treatment. However, limited availability is mainly due to high costs and facility size. Our goal is to design a more compact and cost-effective multi-room particle therapy facility using a cyclotron-based proton therapy...
Purpose
In-vivo range verification of proton therapy with PET provides a unique opportunity for 3D verification of treatment fields delivered to patients. In-beam and inter-field imaging is possible with use of an open-ring design, allowing uninterrupted delivery of treatment fields. We present the first proof of concept measurements for full in-beam and inter-field imaging using the recently...
Purpose
To evaluate the robustness of proton treatment plans to relative biological effectiveness (RBE) uncertainties based on target coverage and tissue toxicity using a normal tissue complication probability (NTCP) model.
Methods
Two different clinically used treatment planning techniques, a four-field and a six-field technique, combined with two optimization methods, planning target...
Purpose
For a cyclotron-based facility, one of the methods for improving beam transmission is to transport higher emittance through the beamline, which can lead to larger beam sizes and/or divergence with respect to the ideal treatment planning requirements. A similar problem exists in multi-room facilities, where small differences between the transport beam lines for each treatment room...
Purpose: Non-isocentric dynamic trajectory radiotherapy (DTRT) is enabled through dynamic table translations in synchrony with intensity modulation and dynamic gantry, table and/or collimator rotation. Non-isocentric DTRT was shown to improve delivery time for craniospinal irradiation (CSI) compared to multi-isocentric intensity modulated radiotherapy (IMRT) by moving the table longitudinally...
Purpose: Dynamic-collimator trajectory radiotherapy (colli-DTRT) delivers intensity modulated radiotherapy with non-coplanar partial arcs and dynamic-collimator rotation. We compare two path-finding approaches for colli-DTRT, geometric and dosimetric, investigating the impact of organ-at-risk (OAR) prioritization on the path-finding and dosimetric plan quality.
Methods: In the...
Purpose: To develop robust dynamic-collimator trajectory radiotherapy (colli-DTRT), including robust dosimetrically motivated path-finding, to manage patient set-up uncertainties.
Methods: colli-DTRT plans were created for one brain (30 x 2 Gy) and one breast (16 x 2.65 Gy) clinically motivated cases. colli-DTRT paths were generated through iterative fluence map optimization (FMO) and beam...
