Gebhard Schertler (Paul Scherrer Institut)
Dr Karol Nass (Max Planck Institute for Medical Research)
Serial femtosecond crystallography (SFX) is an emerging technique for protein structure determination. SFX has been proposed as the method of choice for data collection of highly radiation sensitive systems such as nanocrystals in general and e.g. metalloproteins. Previous high resolution SFX measurements performed at the LCLS do not show any signs of radiation damage at a dose of <100 MGy....
Dr Matthias Frank (Lawrence Livermore National Laboratory)
Over the last years, serial femtosecond nanoscrystallography (SFX) has been demonstrated successfully in a number of experiments at LCLS and SACLA. Most SFX appllications to date have used three-dimensional (3D) nano- or microcrystals and have utilized a liquid jet based sampe introduction approach. That approach typically requires large amounts of sample and is not conducive to measuring...
Sebastien Boutet (Linac Coherent Light Source)
One of the early success stories of XFELs is the technique of Serial Femtosecond Crystallography (SFX), where crystals are illuminated by the x-ray pulses one at a time and the biomolecular structure is deduced from integrating all these measurements. After a few years of development, the technique has reached some level of maturity. In this talk I will quickly review the state of...