Speaker
Mr
Victor Oliveros Colón
(Mamaself)
Description
Multi-responsive polymers have gained a lot of attention, mainly due to the huge array of applications [1] they can be used for, such as sensors, drug delivery systems or tissue engineering. In this work, core-shell micelles with a pH-responsive shell, whose shell blocks undergo a phase transition from expanded to collapsed as a response to changes on the pH, are investigated. At higher concentration, network formation is found, and the phase transition results in strong changes of the mechanical properties [2,3]. Here, we focus on the structural changes.
Two block copolymers were investigated in this work PMMA-b-PDMAEMA-b-PMMA (PMMA and PDMAEMA are poly(methyl methacrylate) and poly[2-(dimethyl amino) ethyl methacrylate]) and PMMA-b-PDMAEMA-b-P2VP-b-PDMAEMA-b-PMMA (where P2VP stands for poly(2-vinylpyridine)). Both block copolymers have similar architectures, ABA and ABCBA, with small hydrophobic blocks A in the outer part of the chain and large pH-responsive blocks B and C in the inner part. While PDMAEMA is a weak polycation, P2VP is a strong one and becomes hydrophobic at high pH values.
To study structural changes under different conditions, solutions of the polymers were prepared in D2O at different concentrations (0.1-1 wt%) and pD values (1, 4 and 7). Synchrotron small-angle X-ray scattering experiments were carried out at the beamline D1 at CHESS to investigate the structure of the micelles.
References
[1] C. Tsitsilianis, Soft Matter, 2010, 6, 2372.
[2] F. Bossard, T Aubry, G. Gotzamanis, C. Tsitsilianis, Soft Matter, 2006, 2, 510.
[3] G. Gotzamanis, C. Tsitsilianis, S. C. Hadjiyannakou, C. S. Patrickios, Macromolecules, 2006, 39, 678.
Primary author
Mr
Victor Oliveros Colón
(Mamaself)
Co-authors
Dr
Christine Papadakis
(TUM)
Mr
Constantinos Tsitsilianis
(University of Patras)
Dr
Detlef Smilgies
(Cornell University)
Mr
Florian Jung
(TUM)
