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12th International Workshop on Radiation Damage to Biological Samples

3–5 Jun 2025
Paul Scherrer Institut
Europe/Zurich timezone
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Session

Pump-Laser Excitation Conditions in Time-Resolved Serial Femtosecond Crystallography

LAS
5 Jun 2025, 09:00
Auditorium (Paul Scherrer Institut)

Auditorium

Paul Scherrer Institut

Forschungsstrass 111 5232 Villigen PSI Switzerland

Conveners

Pump-Laser Excitation Conditions in Time-Resolved Serial Femtosecond Crystallography

  • Philip Johnson (PSI - Paul Scherrer Institut)

Presentation materials

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  1. 18. Ultrafast structural changes in myoglobin: influence of pump laser fluence
    Thomas R.M. BARENDS (Max Planck Institute for Medical Research)
    05/06/2025, 09:00
    Invited

    The high-intensity femtosecond pulses generated by X-ray free-electron lasers enable pump-probe studies of electronic- and nuclear changes during light-induced reactions. On time scales from femtoseconds to milliseconds and for a variety of biological systems, time-resolved serial femtosecond crystallography (TR-SFX) has provided detailed structural data on processes such as light-induced...

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  2. 25. Time-resolved serial femtosecond crystallography on the fluorescent protein rsEGFP2-V151A in different photon excitation regimes
    Nicolas COQUELLE (CNRS Grenoble)
    05/06/2025, 09:30
    Invited

    Time-resolved serial femtosecond crystallography (TR-SFX) enables the visualization of ultrafast structural changes in crystalline macromolecules [1]. For light-sensitive proteins, optical excitation lasers represent a convenient means to trigger the reaction. Generally, high excitation-laser fluences are used to maximize light-induced features in the Fourier difference electron density maps...

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  3. 23. Structural effects of high laser power densities on an early bacteriorhodopsin photocycle intermediate
    Jörg STANDFUSS (PSI - Paul Scherrer Institut)
    05/06/2025, 10:00
    Invited

    Time-resolved serial crystallography at X-ray Free Electron Lasers offers the opportunity to observe ultrafast photochemical reactions at the atomic level. The technique has yielded exciting molecular insights into various biological processes including light sensing and photochemical energy conversion. However, to achieve sufficient levels of activation within an optically dense crystal, high...

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