Speaker
Mr
Kevin Mader
(Paul Scherrer Institute)
Description
Osteoporosis leads to a higher risk of bone fracture through decreased bone mass and architectural changes leading to decreased bone quality. While bone mass through bone mineral density (BMD) is the most important factor in assessing fracture risk, introducing architecture through morphological parameters in cortical femur bone, one of the most problematic and debilitating fracture regions, can significantly increase the predictive power. Correlating these findings with genetic information would provide the basis to begin human studies and eventually personal medicine assessing risk and targeting therapies based on genetic information.
Although structural studies of cortical microstructure have been previously conducted with x-ray tomography, sample counts have typically been small. In order to map the genetic contribution, thousands of samples are needed. For our study we are using the femur bones from 1200 mice of controlled genetic background. To enable this study we developed automated measurement (robot, alignment, ROI detection) tools in combination with automated analysis (segmentation, morphological analysis) and a system to track samples through the entire process.
Please specify the session
Imaging
Please specify poster or talk
poster
Primary author
Mr
Kevin Mader
(Paul Scherrer Institute)
Co-authors
Prof.
Marco Stampanoni
(Paul Scherrer Institute)
Dr
Philipp Schneider
(ETHZ)
Prof.
Ralph Müller
(ETHZ)
