6-8 May 2018
US/East-Indiana timezone

- "XRPD refreshers"

Special session: 'XRPD Refreshers: an informal tutorial on X-Ray Powder Diffraction (XRPD) and Synchrotron X-Ray Powder Diffraction (S-XRPD)' 
Fabia Gozzo, Pamela Whitfield and Mathilde Reinle-Schmitt, Excelsus Structural Solutions
Robert von Dreele, Argonne National Laboratory, Chicago



On Sunday May 6th afternoon, a complimentary tutorial session on X-Ray Powder Diffraction and the advantages of using Synchrotron radiation is organized. This informal session is addressed to those participants who might not be very familiar with XRPD and synchrotron-XRPD or might enjoy a refresh of basic principles. The afternoon is divided in 5 parts:

Part1: Crystalline drugs and their diffraction patterns
•          Elements of crystallography & X-Ray Diffraction
•          Powder diffraction vs Single Crystal Diffraction
•          Specificities of organics & qualitative interpretation of their diffraction patterns
•          Structural analysis of drug substances and products
 
Part 2: The importance of powder sample preparation: how can it influence the output of our experiments/measurements?
•          Does a powder sample always behave as a powder?
•          The choice of the experiment configuration (transmission vs reflection)
•          The choice of the detectors: is high-resolution always the best choice?
•          How should we prepare samples? Tips
•          What if we cannot control all parameters?
 
Part 3: Laboratory versus synchrotron XRPD: when is lab-XRPD no longer the best choice?
•          What is a synchrotron? Why does it enable you to learn more about your sample?
•          Laboratory vs synchrotron source: are they complementary?
•          LOD & LOQ
•          Synchrotron-XRPD: measurements or experiments?
•          Synchrotron-based analytical techniques: how does a company access them?
 
Part 4: In practice – What does a diffraction pattern tell us at glance? What else can it tell us?
•          Indexation, Structure Solution and Refinement
•          Trace analysis & Quantitative Phase Analysis
•          Microstructure analysis of pharmaceuticals
•          Pair Distribution Function analysis of pharmaceuticals: definitions, aim of analyses, complexity
 
Part 5: Can XRPD analyze systems as complex as proteins?
•          The pioneer work of Robert von Dreele, Irene Margiolaki and Jonathan Wright
 

 
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