Special session: 'XRPD Refreshers: an informal tutorial on X-Ray Powder Diffraction (XRPD) and Synchrotron X-Ray Powder Diffraction (S-XRPD)'
Fabia Gozzo, Pamela Whitfield and Mathilde Reinle-Schmitt, Excelsus Structural Solutions
Robert von Dreele, Argonne National Laboratory, Chicago
On Sunday May 6th afternoon, a complimentary tutorial session on X-Ray Powder Diffraction and the advantages of using Synchrotron radiation is organized. This informal session is addressed to those participants who might not be very familiar with XRPD and synchrotron-XRPD or might enjoy a refresh of basic principles. The afternoon is divided in 5 parts:
Part1: Crystalline drugs and their diffraction patterns
• Elements of crystallography & X-Ray Diffraction
• Powder diffraction vs Single Crystal Diffraction
• Specificities of organics & qualitative interpretation of their diffraction patterns
• Structural analysis of drug substances and products
Part 2: The importance of powder sample preparation: how can it influence the output of our experiments/measurements?
• Does a powder sample always behave as a powder?
• The choice of the experiment configuration (transmission vs reflection)
• The choice of the detectors: is high-resolution always the best choice?
• How should we prepare samples? Tips
• What if we cannot control all parameters?
Part 3: Laboratory versus synchrotron XRPD: when is lab-XRPD no longer the best choice?
• What is a synchrotron? Why does it enable you to learn more about your sample?
• Laboratory vs synchrotron source: are they complementary?
• LOD & LOQ
• Synchrotron-XRPD: measurements or experiments?
• Synchrotron-based analytical techniques: how does a company access them?
Part 4: In practice – What does a diffraction pattern tell us at glance? What else can it tell us?
• Indexation, Structure Solution and Refinement
• Trace analysis & Quantitative Phase Analysis
• Microstructure analysis of pharmaceuticals
• Pair Distribution Function analysis of pharmaceuticals: definitions, aim of analyses, complexity
Part 5: Can XRPD analyze systems as complex as proteins?
• The pioneer work of Robert von Dreele, Irene Margiolaki and Jonathan Wright
Fabia Gozzo, Pamela Whitfield and Mathilde Reinle-Schmitt, Excelsus Structural Solutions
Robert von Dreele, Argonne National Laboratory, Chicago
On Sunday May 6th afternoon, a complimentary tutorial session on X-Ray Powder Diffraction and the advantages of using Synchrotron radiation is organized. This informal session is addressed to those participants who might not be very familiar with XRPD and synchrotron-XRPD or might enjoy a refresh of basic principles. The afternoon is divided in 5 parts:
Part1: Crystalline drugs and their diffraction patterns
• Elements of crystallography & X-Ray Diffraction
• Powder diffraction vs Single Crystal Diffraction
• Specificities of organics & qualitative interpretation of their diffraction patterns
• Structural analysis of drug substances and products
Part 2: The importance of powder sample preparation: how can it influence the output of our experiments/measurements?
• Does a powder sample always behave as a powder?
• The choice of the experiment configuration (transmission vs reflection)
• The choice of the detectors: is high-resolution always the best choice?
• How should we prepare samples? Tips
• What if we cannot control all parameters?
Part 3: Laboratory versus synchrotron XRPD: when is lab-XRPD no longer the best choice?
• What is a synchrotron? Why does it enable you to learn more about your sample?
• Laboratory vs synchrotron source: are they complementary?
• LOD & LOQ
• Synchrotron-XRPD: measurements or experiments?
• Synchrotron-based analytical techniques: how does a company access them?
Part 4: In practice – What does a diffraction pattern tell us at glance? What else can it tell us?
• Indexation, Structure Solution and Refinement
• Trace analysis & Quantitative Phase Analysis
• Microstructure analysis of pharmaceuticals
• Pair Distribution Function analysis of pharmaceuticals: definitions, aim of analyses, complexity
Part 5: Can XRPD analyze systems as complex as proteins?
• The pioneer work of Robert von Dreele, Irene Margiolaki and Jonathan Wright
