SPS-XRPD Workshop

Session

In-situ S-XRPD

7 May 2018, 13:25

11. Monitoring phase transformations in formulations

Prof. Raj Suryanarayanan (College of Pharmacy, University of Minnesota)

07/05/2018, 13:25

Monday, May 7th Afternoon (Day 1 Workshop)

The disproportionation of pioglitazone hydrochloride in intact tablets was mapped by transmission-mode synchrotron X-ray diffractometry (SXRD; Argonne National Laboratories). Tablet mapping was performed in situ at the beamline using a custom-built temperature and humidity controlled setup. Presence of basic excipients (magnesium stearate or croscarmellose sodium) caused disproportionation,...

12. Using Containerless Methods to Synthesize and Characterize Amorphous Pharmaceuticals

Dr Richard Weber (Materials Development, Inc. and Argonne National Laboratory)

07/05/2018, 13:50

Monday, May 7th Afternoon (Day 1 Workshop)

This talk will focus on the application of non-contact (containerless) methods, such as acoustic levitation, to access metastable and amorphous forms of organic compounds. The complete absence of extrinsic nucleation sites in containerless conditions enables deep supercooling and/or extreme supersaturation to be achieved for a wide variety of compositions. The ability to extend the glass...